The dose – response relationship, or exposure–response relationship, describes the change in effect on an organism caused by differing levels of exposure (or doses) to a stressor (usually a chemical) after a certain exposure time, or to a food. Definition of dose response relationship: Measurement of the relationship between the quantity of a substance or exposure to radiation (the dose) and its overall effect (the response) on an organism. Response may shift dramatically with. Dose – response relationship, effect on an organism or, more specifically, on the risk of a defined outcome produced by a given amount of an agent or a level of exposure. A dose – response relationship is one in which increasing levels of exposure are associated with either an increasing or a decreasing risk of the outcome.
Dose response and dose effect are fundamental descriptors of events occurring after an exposure.
Although the field of toxicology continues to explode with the development of new techniques, models, and “-omics” areas of study, these underlying concepts remain invaluable and are the common threads that link these . A dose response curve is one of the most important concepts in pharmacology and describes the relationship between an effect of a drug and the. Dose – response curve definition, a curve plotting the relationship between the dose of a drug administered and its pharmacological effect. Doses lower than the threshold produce no response while those in excess of the threshold exert no additional response. The shape of the curve is usually hyperbolic when plotted with linear axes and gives a sigmoidal curve when response is plotted versus the log of the dose. One particular instance in which this dose – response relationship does not hold true, is in regard to true allergic reactions.
The difference between allergies and toxic reactions is that a toxic effect is directly the result of . An abbreviated history of the dose – response curve or chemical concentration- effect relationship is presented in this article. No attempt has been made to include all references on the subject.
Just an outline, overview, and discussion of the most important eras are presented. The history of dose response may be divided . The dose – response relationship in phase I clinical trials and beyond: use, meaning, and assessment. Emilien G(1), van Meurs W, Maloteaux JM.
When we graph the dose of a substance and the percentage of a population that responds to that dose, the result is called the dose – response curve. The x-axis is the dose, typically in a logarithmic scale. This means units on the x-axis increase by a power of 10 . Knowledge of the relationships among dose, drug concentration drug concentration in bloo and clinical response ( effectiveness and undesirable effects) is important for the safe and effective use of drugs in individual patients. This information can help identify an appropriate. THIS chapter focuses on dose – response analysis and its role in choosing a point of departure to be used in the risk assessment for MeHg.
The chapter begins with a brief review of risk assessment for noncancer end points. Problems with the traditional approach that is based on no-observed-effect levels (NOAELs) will be. If there is sufficient plausibility for the presence of.
Dose – response data may be derived from in vivo studies in animals or humans, which.