These natural chemicals most likely contribute to plant defence . Recent studies have shown beneficial effects of glucosinolates , including regulatory functions in inflammation, stress response, phase I metabolism, . Epidemiological studies suggest that brassica vegetables are protective against cancers of the lungs and alimentary tract. Cruciferous vegetables are the dietary source of glucosinolates , . Unique secondary metabolites, glucosinolates (S-glucopyranosyl thiohydroximates), are naturally occurring S-linked glucosides found mainly in Brassicaceae plants.

They are enzymatically hydrolyzed to produce sulfate ions, D-glucose, and characteristic degradation products such as isothiocyanates. After ingestion, glucosinolates could be partially absorbed in their intact form through the gastrointestinal mucosa. However, the largest fraction is metabolized in the gut lumen. In the plant, they coexist with an endogenous ? After physical damage to the plant tissue, glucosinolates are broken down, by the endogenous enzyme myrosinase, releasing glucose and a complex variety of biologically active products.

Although isothiocyanate and indole compounds derived from crucif- erous vegetables appear to be struc- turally unrelate they are both derived from glucosinolates. The most important and .

These sulfur-con- taining glycosides are found in the order Capparales, which includes the. Studies suggest that glucosinolates provide health benefits. Each theme will be introduced by invited keynote speakers and followed by presentations selected from the participants.

We explicitly aim to foster integration. GLUCOSINOLATES – INFORMATION SHEET. They are modified amino acids, carrying an S-glucose functional group and a variety of different side chains. Glucosinolates are the main secondary, sulphur-containing metabolites found in Brassica crops. During food preparation, chewing, and digestion, the glucosinolates in cruciferous vegetables are broken down to form biologically active compounds such as indoles, nitriles, thiocyanates, and isothiocyanates (1).

Indole-3-carbinol (an indole) and sulforaphane (an isothiocyanate) have been most . As such, glucosinolates act as indirect antioxidants triggering the liver to produce detoxifying enzymes that block free-radical attack on DNA. Once this process occurs, a cascade of . Methionine and cysteine are the natural donors in the case of the Brassica plants and L- tryptophane in the indole glucosinolates , respectively. In Brassica genus, alkenyl glucosinolates. Sigma-Aldrich Online Catalog Product List: Glucosinolates.

ChEBI Name, glucosinolate.

Definition, Water-soluble anionic substituted thioglucosides. Dinkova- Kostovaand Rumen V. Division of Cancer Research, Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee. Department of Pharmacology and Molecular. They generally consist of a sugar entity, b-D- thioglucose, with an ester bond to an organic aglycone that is an alkyl group yielding isothiocyanate, nitrile, thiocyanate or a similar compound upon hydrolysis. These compounds often contribute a bitter, hot taste to condiments . Annual Review of Entomology.

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